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Buy Ranexa Online

Ranexa is an effective prescription drug that helps treat the symptoms of Angina (chest pain). Your healthcare professional may prescribe this drug to you alone or in combination with specific other medications. Buy Ranexa Online 

Ranexa belongs to the antianginal (or non-nitrates) category of medications known for their potent in dealing with chest pain. Although, it is still unknown whether this drug is safe and effective in children from 0 to 18 years. 

Ranexa Description

Ranexa generic version is available as ranolazine (extended-release tablets). It is a racemic mixture that may look as white or off-white solid to you. Ranolazine is soluble in methanol and dichloromethane; sparingly soluble in ethanol, tetrahydrofuran, acetone, and acetonitrile; slightly soluble in isopropanol, acetate, ethyl ether, and toluene; and very slightly soluble in water. 

Ranexa tablets consist of 500 mg or 1000 mg of ranolazine along with the following inactive ingredients:

  • hypromellose
  • carnauba wax
  • magnesium stearate
  • methacrylic acid copolymer (Type C)
  • polyethylene glycol
  • microcrystalline cellulose
  • titanium dioxide, and
  • sodium hydroxide

Additional inactive Buy Ranexa Online ingredients for the 500 mg tablet include talc, polyvinyl alcohol, Iron Oxide Red, and Iron Oxide Yellow: other passive products for the 1000 mg tablet include triacetin, lactose monohydrate, and Iron Oxide Yellow. 

What are the side effects of Ranexa?

Ranexa may cause some severe side effects, including:

  • fast or pounding heartbeats
  • lightheadedness
  • little or no urination
  • fluttering in your chest
  • swelling in your feet or ankles
  • painful or difficult urination
  • shortness of breath
  • feeling tired

You should take instant medical help or consult your healthcare professional if any of the symptoms listed above occur. The most common adverse effects of Ranexa may include constipation, nausea, dizziness, and headache. 

Indications and Dosage

Ranexa is beneficial for the treatment of chronic Angina. It may also be used with nitrates, beta-blockers, anti-platelet therapy, calcium channel blockers, ACE inhibitors, lipid-lowering therapy, and angiotensin receptor blockers. 

Ranexa Dosage

You should start the treatment with 500 mg twice daily and increase the dose to 1000 mg twice daily, depending on clinical symptoms. You can take it either with food or without any meal. Swallow the whole Ranexa tablets without crushing, breaking, or chewing them. 

The maximum amount per day should not be more than 1000 mg two times a day. If a dose of this drug is missed, take the recommended dose at the following schedule; do not repeat or double the subsequent amount. 

How Supplied: Dosage Forms and Strengths?

It would help if you took Ranexa precisely as per the doctor’s prescription. 

Ranexa is supplied as oblong-shaped, film-coated, extended-release capsules following this: 

  • 500mg tablets are light orange with GSI500 on one side
  • 1000mg tablets are pale yellow, with GSI1000 on one side

Although, a lower strength of Ranexa 375 mg is also available. 

How do other drugs affect Ranexa?

Strong CYP3A inhibitors

The plasma level of this drug with Ranexa 500 mg or 1000 mg twice a day is increased by 220 percent when an individual takes it with ketoconazole 200 mg twice daily. 

Moderate CYP3A inhibitors

Plasma levels of Ranexa 1000 mg two times a day are increased by 50 mg to 130 percent by diltiazem 180 mg to 360 mg, respectively. Plasma levels of Ranxexa 750 mg twice a day are increased by 100 percent if you take verapamil 120 mg with this drug three times a day. 

Weak CYP3A Inhibitors: The weak CYP3A inhibitors cimetidine (400 mg thrice a day) and simvastatin (20 mg once a day) do not increase ranolazine exposure in healthy volunteers. 

CYP3A Inducers: If you take Rifampin 600 mg one time a day, it decreases the plasma concentrations of ranolazine (Ranexa 1000 mg two times a day) by approximately 95 percent. 

CYP2D6 Inhibitors: If you increase the daily dose of Paroxetine 20 mg, it may increase the ranolazine concentrations by 20 percent in healthy people taking this drug in 1000 mg two times a day. No dosage adjustment of Ranexa is needed in people getting treatment with CYP2D6 inhibitors. 

Warnings and Precautions

QT Interval Prolongation

Ranolazine prolongs the QT interval in a dose-related form. The clinical experience did not report that any acute coronary syndrome population did not present an increased risk of proarrhythmia or sudden death. However, the high doses may hit differently. Exposure to QT-prolonging drugs potassium channel variants can lead to prolonged QT intervals. The risk is higher in patients with a family history of long (or congenital) QT syndrome or individuals with known acquired QT interval prolongation. 

Renal Failure

Renal failure has been reported to some patients with renal impairment while taking Ranexa. If an acute renal failure occurs, discontinue the drug and treat it appropriately. You may need a healthcare professional to monitor renal function after beginning and periodically in individuals with moderate to severe renal impairment. 

Use in Specific Populations

Pregnancy

There is insufficient available data on Ranexa use in pregnant women to inform of any drug-related risks. Studies in animals (rats and rabbits) showed no such evidence of fetal harm at exposures four times the maximum prescribed human dose. 

In the United States general population, the estimated risk of significant congenital disabilities (congenital difficulties) and a miscarriage of clinically recognized pregnancies is 2 to 4 percent and 15 to 20 percent. 

Lactation

There are no specific data on the presence of ranolazine in breast milk, the effects on the nursing infant, or the effects on milk production. The health benefits of breastfeeding should be considered together with the mother’s clinical requirement for Ranexa and any potential side effects on the nursing infant or the underlying maternal condition. 

Ranexa Overdose

This product’s high oral doses can increase nausea, dizziness, and vomiting for an extended period. High intravenous exposure also leads to the production of paresthesia, diplopia, syncope, and confusion. In addition to supportive measures, continuous ECG monitoring may help during an overdose. 

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