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Scientists, policymakers, and healthcare workers are keen to ascertain to what extent COVID-19 may be seasonal. By understanding this aspect of the disease, we could guide our response to the pandemic.
UC Santa Barbara’s researchers have found evidence that the spread of COVID-19 is sensitive to UV exposure. In contrast, this suggests that COVID-19 may vary with the seasons, other seasonal factors such as temperature, specific humidity, and precipitation—whose effects are uncertain according to the available data. The results came in the Proceedings of the National Academy of Sciences.
According to co-author Kyle Meng, “Resembling species of coronavirus such as SARS from 2003 and MERS from 2012, turned out to have weak relationships with temperature and humidity, but were sensitive to UV radiation”. Kyle Meng is an environmental economist in UC Santa Barbara’s economics department and at the campus’s Bren School of Environmental Science & Management.
Meng, in collaboration with Tamma Carleton, also at the Bren School, Peter Huybers and Jonathan Proctor from Harvard, and Jules Cornetet at France’s École Normale Supérieure Paris-Saclay, sought to explore the relationship between UV radiation and the spread of COVID-19 by creating a high-resolution global dataset of daily COVID-19 cases.
Many papers compare various locations to get a sense of how the disease reacts to different environmental conditions. But this approach presents a host of potentially confounding factors into statistical models, such as health care quality, income, and cultural norms.
Meng extends the more temperate United States and more tropical Brazil as models. He said, “The U.S. and Brazil differ for a lot of reasons. They differ in economic conditions and institutions, in addition to different environmental conditions.” He said these distinctions prevent a clean comparison of the spread of COVID-19 based solely on environmental conditions.
To overcome this problem, the team carried out a longitudinal study, essentially comparing many populations to themselves over time. So, rather than comparing Brazil to the U.S., they compared communities within Brazil to themselves at a different time, when local environmental conditions changed. “We investigate whether daily fluctuations in environmental conditions experienced by a population affect new COVID-19 cases up to two weeks later,” Meng described.
To achieve this, the researchers required bulk of data. Unfortunately, when the team started their research, international COVID-19 databases, like that of Johns Hopkins, provided data only at the country level. Records with more satisfactory resolution were available across different agencies and institutions in various languages and formats.
“We utilized many diverse datasets from different countries’ statistical agencies and synchronized them to form a global dataset comprised of over 3,000 spatial units,” Carleton said. The authors then employed a dataset of meteorological conditions with a daily resolution to match local environmental circumstances to daily counts of COVID-19 cases.
The researchers employed a set of statistical techniques to analyze how four variables viz. UV radiation, temperature, humidity, and precipitation—correlated with the daily growth rate of COVID-19 cases, a measure for how rapidly the disease was spreading in a region. They also evaluated the lag time between changes in environmental conditions and possible effects on recorded COVID cases, which could be significant given the virus’s 4 to 7 day incubation period, along with additional testing delays.
The team manifested that a location’s UV exposure profoundly affects COVID-19 transmission. A shift in UV exposure by one standard deviation (approximately equal to the difference in UV between May and June in Los Angeles) diminished the growth rate of new cases by around one percentage point over the following two weeks. It means that it could bring down COVID-19 growth rates from an average daily increase at the beginning of the epidemic of 13% to a 12% increase per day.
Based on the expected UV radiation’s seasonal changes, the model predicted growth rates would increase by 7.3 percentage points for southern temperate locations between January and June. While, northern temperate regions would see a UV-driven decrease of 7.4 percentage points during that same period, as longer days increased UV exposure.
This pattern shifts as the seasons change. By December, the researchers predicted COVID-19 growth rates could decline by around 7.7 percentage points in southern temperate zones, with July numbers, while cooler northern areas could see an inflation of 7.8 percentage points over this period.
Notably, the seasonal influence of UV on the transmission of the disease is small compared to that of social distancing policies such as travel restrictions, school closures, or home isolation, the authors noted. Regardless of the weather, social distancing measures appear to be necessary to slow the spread substantially.
The infection rates appear to have decreased in the northern hemisphere during the summer, possibly due to increased UV exposure, which confirms these findings. However, many regions also relaxed their COVID stay-at-home orders simultaneously, Meng said. Due to this, there’s a conflation between UV effects and easing the restrictions during the summer months. “This is a huge reason why our study utilizes daily fluctuations in UV exposure to avoid conflating influencing factors when studying long-term, varying fluctuations.”
The U.S. is currently experiencing a rise in COVID-19 infections with winter’s arrival, and these findings are consistent with these concerns. According to Carleton, “We are confident of the UV effect, but this is only one piece of the full seasonality picture.”
Lab studies will eventually be crucial in exploring the mechanisms at work. However, the authors suspect multiple factors may be behind UV’s effect on COVID-19 transmission, some of which are difficult to study in the lab- the first one is biological. UV can damage the nucleic acids that the virus utilizes to encode its genetic information. Co-author Jonathan Proctor, a post-doctoral fellow at Harvard, posited that UV radiation might inactivate the virus as transmitted, such as when it’s suspended in the air or resting on an exposed surface. “Just as UV can destroy our DNA if we don’t use sunscreen, UV can damage the COVID-19 virus,” Proctor said.
Another component is behavioral. For instance, people may go out more often when it is more sunshiny, altering transmission risk. While laboratory studies are useful in determining biological mechanisms, population-level studies like this can also consider social factors.
“In this context, our study suggests that seasonal changes in UV may affect COVID-19 transmission in the months to follow,” Meng said. “And if that’s true, we need to contemplate ways of modulating COVID-19 containment policies seasonally.”
Written by Lucy Lawless
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